Instruct-ERIC Biennial Structural Biology Conference
Cascais, Lisbon
Portugal
23 – 24 May 2024
Registration Deadline - Passed
The Instruct Biennial Structural Biology Conference (IBSBC) showcases the latest in integrative structural biology from leading scientists across the world. The theme for the conference is "New Directions for Structural Biology".
The 6th Instruct Biennial Structural Biology Conference will be held in Cascais, Portugal, 23-24 May.
Please note: 22nd May will see a number of closed internal Instruct-ERIC meetings, including the Centres Forum and Managers Meeting.
The conference will explore the latest cutting-edge developments in structural biology, including the emerging methods in imaging technologies, artificial intelligence and more, as well as insight into the role structural biology plays in the wider global context.
The local organising committee for the Biennial is Carlos Cordeiro and Marta Sousa Silva (FC-Lisboa), and Madalena Gallagher, John Dolan, and Claudia Alén Amaro (Instruct-Hub).
Carlos Cordeiro
FC-Lisboa, Portugal
Maria Macias
IRB Barcelona, Spain
Roberta Pierattelli
CERM, Italy
Eaazhisai Kandiah
ESRF, France
Friedrich Forster
University of Utrecht, Netherlands
Margarida Archer
ITQB NOVA, Portugal
Kristina Djinovic-Carugo
EMBL Grenoble, France
Harald Schwalbe
Goethe University, Germany
Jan Steyaert
VIB-VUB Brussels, Belgium
Carmen San Martín
CNB-CSIC Madrid, Spain
Kresten Lindorff-Larsen
University of Copenhagen, Denmark
Markus Weingarth
Bijvoet Centre, Netherlands
Olivier Duss
EMBL Heidelberg, Germany
Tanja Mittag
St Jude Children's Research Hospital, USA
Jan Schuller
SYNMIKRO Research Centre, Germany
Tzviya Zeev-Ben-Mordehai
Utrecht University, Netherlands
Neil Kelleher
Northwestern University, USA
Priya Ramakrishna
EPFL, Switzerland
Tassos Perrakis
Netherlands Cancer Institute, Netherlands
Stephan Rauschenbach
University of Oxford, UK
Andrea Thorn
Universiteit Hamburg, Germany
Courtney Tremlett
University of Exeter, UK
Maria Del Rosario Fernandez Fernandez
CINN-CSIC, Spain
Anna Stefanik Sobotkova
CEITEC, Czech Republic
Jordan Chill
Bar Ilan University, Israel
Guilherme Vilela-Alves
UCIBIO@NOVA-FCT, Portugal
Sarah Butcher
University of Helsinki, Finland
Sarah Lowen
UCL, UK
Catarina Malta
iBET, Portugal
Gints Kalnins
LBMC, Latvia
Loïck Moisonnier
IBCP, France
Angela Sofia Tino
CERM, Italy
See the full Instruct Biennial Structural Biology Conference programme here.
9:00 - 17:00 Manager's Meeting, Centre's Forum, and Executive Committee [Closed]
Session One - Structural Biology Meets AI plus MDChairs: Carlos Cordeiro and Maria J Macias |
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| Time | Speaker | Institution | Title |
| 9:00 - 9:10 | Madalena Alves | President of the Direction Council of FCT | Opening Ceremony |
| 9:10 - 9:50 | Jan Steyaert | VIB-VUB Centre |
Engineering Nanobodies for Structural Biology & Drug Discovery |
| 9:50 - 10:05 | Sjors Scheres | MRC Cambridge | Presentation of the Ivano Bertini Award |
| 10:05 - 10:30 | Bertini Award Winner - Martin Blackledge |
NMR Provides Unique Insight into the Functional Dynamics and Interactions of Intrinsically Disordered Proteins |
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| 10:30 - 11:00 | Break | ||
| 11:00 - 11:40 | Tassos Perrakis | Netherlands Cancer Institute |
After the AlphaFold revolution: AI-enabled adventures in integrative structural biology |
| 11:40 - 12:20 | Andrea Thorn | Universiteit Hamburg |
The potential of AI for biomolecular structure determination, prediction and validation |
| 12:20 - 12:30 | Courtney Tremlett | University of Exeter |
Small but mighty: The power of microcrystals in protein structural biology |
| 12:30 - 12:40 | Gints Kalnins | Latvian Biomedical Research and Study Centre |
Structural basis for inhibition of the SARS-CoV-2 nsp16 by substrate-based dual site inhibitors |
| 12:40 - 13:20 | Kresten Lindorff-Larsen | University of Copenhagen |
Biophysical experiments and biomolecular simulations: A perfect match? |
| 13:20 - 14:15 | Lunch | ||
Session Two - Structural Biology For Health and the EnvironmentChairs: Eaazhisai Kandiah and Margarida Archer |
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| Time | Speaker | Institution | Title |
| 14:15 - 14:55 | Neil Kelleher | Northwestern University |
Structural biology at the level of proteoforms and their complexes using single molecule mass spectrometry |
| 14:55 - 15:15 | Rebecca Thompson | Thermofisher |
From Structures to In Situ - latest developments in cryoEM |
| 15:15 - 16:30 | Even-Number Poster Session and Tea/Coffee | ||
| 16:30 - 17:10 | Markus Weingarth | Utrecht University |
The Mechanism of Lipid-targeting Antibiotics |
| 17:10 - 17:20 | Maria Del Rosario Fernandez Fernandez | CINN-CSIC |
Disruption of the mitochondrial network in a mouse model of Huntington's Disease visualized by in-tissue multiscale 3D electron microscopy |
| 17:20 - 17:30 | Angela Sofia Tino | CERM/CIRMMP |
NMR-based investigation of intrinsically disordered regions of modular proteins for tailored drug-design |
| 17:30 - 17:40 | Guilherme Vilela Alves | FCT PT |
Unveiling O2 damage on Mo/W Formate dehydrogenases and their innate protection mechanism |
| 17:40 - 17:50 | Sarah Lowen | University College London | Using NMR spectroscopy to study the pathological linkage in alpha-1-antitrypsin polymers |
| 17:50 - 18:30 | Tzviya Zeev-Ben-Mordehai | Utrecht University | Structural Biology: go bigger, go native |
| 18:45 - 19:45 | Odd-Number Poster Session and Drinks | ||
| 20:00 | Conference Gala Dinner | ||
Session Three - Structural Biology at the Interface with Imaging TechnologiesChairs: Kristina Djinovic Carugo & Roberta Pierattelli |
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| Time | Speaker | Institution | Title |
| 9:00 - 9:40 | Tanja Mittag | St Jude Children's Research Hospital | Phase separation and emergent properties of condensates |
| 9:40 - 10:20 | Stephan Rauschenbach | University of Oxford | Atomic resolution molecular imaging based on soft-landing electrospray ion beam deposition (ESIBD) |
| 10:20 - 10:50 | Break | ||
| 10:50 - 11:00 | Anna Sobotkova Stefanik | CEITEC | Structure and Infection Mechanism of Phage LUZ19 |
| 11:00 - 11:10 | Loïck Moisonnier | IBCP Lyon | Time-resolved structural transitions of the multidrug transporter BmrA using rapid kinetics and time-resolved cryoEM |
| 11:10 - 11:50 | Olivier Duss | EMBL Heidelberg | Tracking assembly and function of single active protein-RNA complexes in real-time |
| 11:50 - 12:30 | Carmen San Martín | CNB-CSIC | Seeing and touching adenovirus: complementary approaches for understanding assembly and disassembly of a complex virion |
| 12:30 - 12:50 | Daniel Mathieu | Bruker | AI Driven Workflows for Biomolecular NMR |
| 12:50 - 13:00 | Group Photo | ||
| 13:00 - 14:00 | Lunch | ||
Session Four - Structural Biology Towards Global SustainabilityChair: Carlos Cordeiro |
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| Time | Speaker | Institution | Title |
| 14:00 - 14:10 | Catarina Malta | iBET PT | Pushing the Limits of HDX-MS to Study Protein:Fragment Low Affinity Interactions |
| 14:10 - 14:20 | Jordan Chill | Bar Ilan University | The Regulatory Cortactin-WIP complex: Structure and Pharmaceutical Implications |
| 14:20 - 15:00 | Jan Schuller | SYNMIKRO | Molecular Basis of Anaerobic Metabolism - Dissecting the Wood-Ljungdahl Pathway |
| 15:00 - 15:10 | Sarah Butcher | University of Helsinki | Capsid inhibitors of coxsackievirus A9 |
| 15:10 - 15:50 | Priya Ramakrishna | EPFL | Cellular window into salinity stress in plants – A CryoNanoSIMS approach |
| 15:50 - 16:30 | Poster Prize Presentation and Closing | ||
Student Fellowships and Bertini Award
Conference Venue
The Biennial Conference will be taking place at the Hotel Pestana Cidadela Cascais, in Cascais - Portugal. The hotel is located inside the Fortress of Our Lady of Light (Nossa Senhora da Luz de Cascais), built in the 15th century to defend the Cascais coastline and the Tagus River estuary, and to protect Lisbon, the capital of Portugal.
Hotel Pestana Cidadela Cascais,
Av. Dom Carlos I,
2750-310 Cascais,
Portugal
How to Arrive
By Plane
From Lisbon Airport, people can either rent a car to drive to Cascais or take a taxi / tvde. The trip takes about 35-40 min (uber: 27-30 €; bolt: 25-30 €; taxi: 50-60 €).
By Train
Lisbon (Cais do Sodré) to Cascais by train takes roughly 40-45 minutes. The walk from the train station to the conference venue is around 15 minutes.
Further information on directions can be found here.
Confidentiality and use of information
All material presented at the IBSBC2024, including abstracts, oral presentations and posters, must be treated as personal communication and should be cited only with the consent of the author.
Photography or video/audio recording of oral presentations or individual posters is strictly prohibited unless with explicit consent of the meeting organisers and the author.
The content of abstracts, oral and poster presentations are the responsibility of the author(s). Instruct will publish the content of the submitted abstracts without asking for explicit consent from the author(s).
Filming and Photography
Filming and photography will be taking place at the event. Read our Filming and Photography Privacy Policy for more information.
Privacy Policy
Your personal data will be handled in accordance with the Instruct-ERIC Privacy Policy.
Cancellation Policy
Any circumstances beyond the reasonable control of Instruct (force majeure) requires to cancel the event, Instruct will notify the participants of such event without undue delay. Instruct will take reasonable steps to minimise the consequences of the force majeure such as reschedule, change from in person to virtual or shorten (in all cases partially or wholly) the Biennial and any performance related to it.
For termination of contract concerning an event between Instruct and the participant due force majeure, this shall be without any liability for either party, except in so far as has accrued prior to the date on which the termination of the contract takes effect.
Each party to the contract concerning the event shall itself be responsible for all direct and indirect financial consequences affecting it as a result of or in connection with the force majeure. The occurrence of force majeure shall not entitle either party to any additional payment or compensation.
In the event of a cancellation due to force majeure, Instruct will reimburse a participant registered for the cancelled event any payment made to Instruct for participation in such event. Refunds are issued if the Biennial is cancelled by Instruct. The reimbursement shall concern only payments made to Instruct for participation and shall exclude for this purpose any other costs committed by participants or associated with their attendance such as any travel, accommodation etc.
We encourage participants to blog, tweet or otherwise communicate about the meeting (#IBSBC2024). However, dissemination of results or discussion presented at the meeting to anonymous third parties must obtain permission from the presenting author BEFORE communicating any results or discussion to third party groups, message boards, blogs or other online resources (other than your own lab or departments).
If you have specific questions regarding these issues or any other aspects of the conference, please contact the IBSBC2024 organising team.
You can email john@instruct-eric.org or support@instruct-eric.org or call +44 1865 98 86 39 to speak with one of the Instruct-ERIC Hub Team.
