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Instruct-ERIC has put together a Resource Centre with tools, information and support from Instruct and the wider scientific community, to assist research relating to SARS-CoV-2 and COVID-19. If you have resources that you would like to share, get in touch at comms@instruct-eric.org.

 

 

To apply for funded access to structural biology services specifically chosen to enhance research into infectious diseases including SARS-CoV-2, visit the ISIDORe website. Instruct-ERIC has a huge range of facilities accessible via ISIDORe, find out more here.

 

 

Instruct-ERIC Services

 

Many Instruct-ERIC services are available via remote access, where samples can be sent for analysis without the need for researchers to travel. You can view the Technology Availability List by clicking the button below. 

 

                                        View our Technology Availability List                 Request access

 

The table below highlights key technologies from our catalogue that are currently available for priority COVID-19 research. 

 

 

Cryo-Electron Microscopy

A sophisticated technique to obtain quantitative structural information on the atomic scale. Includes electron crystallography, single particle analysis and electron tomography.

X-ray Techniques

Includes a variety of approaches to determine the 3D shape of biomolecules at the atomic level, including diffraction and Bio-SAXS at European synchrotrons. XChem fragment screening also available.

Computational Support

A variety of computing services for bioinformatics, modelling, and image processing for electron microscopy and X-ray crystallography.

Molecular Biophysics

An extensive range of techniques to characterise the structure, function and stability of biological macromolecules, and to obtain kinetic and thermodynamic parameters.

Protein Production

Includes cloning, high throughput expression and purification for the production of challenging proteins.

Magnetic Resonance (NMR)

Used to obtain three-dimensional structural and dynamic information about biomolecules in conditions as close as possible to physiological ones. Solution and solid-state NMR available.

Mass Spectrometry

Used to determine protein identity, abundance, modifications (proteomics), shape and topology (ion mobility), inter-subunit connectivity, and equilibrium dynamics (native MS).

Fragment Screening

A method of identifying small organic molecules (fragments) that bind a biological target (eg protein or nucleic acid). Used to find lead compounds as part of the drug discovery process.

 

 

Resources from the Community

 

Flash Reports

 

Name: SARS-CoV-2 spike in prefusion state (flexibility analysis, 1-up closed conformation)

PDB ID: 6ZP5

Release date: 29 July 2020

Method: Electron Microscopy

Centre: Instruct Centre ES

Find out more 

Name: SARS-CoV-2 spike in prefusion state (flexibility analysis, 1-up open conformation)

PDB ID: 6ZP7

Release date: 29 July 2020

Method: Electron Microscopy

Centre: Instruct Centre ES

Find out more 

Name: SARS-CoV-2 spike in prefusion state

PDB ID: 6ZOW

Release date: 29 July 2020

Method: Electron Microscopy

Centre: Instruct Centre ES

Find out more 

 

 

Special Features

Crowdsourcing SARS-CoV-2 anti-virals

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Keep calm and cure coronavirus: COVID-19 collaborations during lockdown at the Astbury Centre, Instruct Centre UK

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World’s first 1.2 GHz NMR at Instruct Centre IT enables novel functional structural biology research

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