BMRZ, Goethe-University Frankfurt (GUF)

The Center for Biomolecular Magnetic Resonance (BMRZ) is a core research infrastructure at Goethe University Frankfurt (GUF), located on the Riedberg Campus. Established in 2002, BMRZ receives dedicated funding from the State of Hesse and serves as the central hub for all local biomolecular NMR and EPR spectroscopy activities. The center currently hosts 13 NMR spectrometers (ranging from 400 to 1200 MHz), supporting both liquid-state and solid-state applications. All liquid-state NMR systems are equipped with cryogenic probes, and the solid-state NMR suite includes two dynamic nuclear polarization (DNP) installations. In addition, BMRZ operates five EPR spectrometers with capabilities up to 263 GHz.

The BMRZ is recognized as a leading hub for advanced RNA and protein structural biology. With decades of expertise in the study of proteins and nucleic acids, particularly RNA, BMRZ offers unmatched capabilities in time-resolved studies, RNA resonance assignment, and structure determination. This expertise proved critical during the COVID-19 pandemic, supporting high-impact research on RNA folding, ligand binding, and kinetic mechanisms—research efforts that continue today.

BMRZ provides comprehensive support for RNA construct design, production, and purification, ensuring high-quality RNA suitable for a broad range of structural applications. For more specialized needs, users can access our chemo-enzymatic workflows for producing modified RNA, enabling investigations into dynamic aspects of RNA structure and function with high precision.

In addition, BMRZ has been a pioneer in fragment-based screening by NMR for more than 20 years, serving both academic and industrial partners. During the pandemic alone, BMRZ successfully screened over 25 proteins and 20 RNA elements, gaining extensive experience in high-throughput screening, automated analysis, and data integration.

BMRZ also leads in solid-state NMR, including DNP-enhanced applications, and has made significant contributions to the structural biology of key membrane protein families such as GPCRs, ABC transporters, and photoreceptors. With this diverse and deeply integrated expertise, BMRZ stands as an invaluable resource for researchers seeking to drive innovation in translational structural biology. BMRZ has a strong record in providing user access in e.g. through iNEXT and iNEXT-Discovery  schemes and has also coordinated initiatives such as EAST-NMR, WeNMR and Remote-NMR.

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