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View All Electron Microscopy at Instruct
The facility provides access to state-of-the-art cryo-EM instrumentation, including automated workflows for single particle data analysis, electron cryo-tomography, lamella preparation, and correlative imaging.
The cryo-EM facility offers the following workflows:
Tailored support is provided for Instruct users, including project feasibility assessments, proposal preparation, and scheduling support.
This service provides cryo-electron tomography data acquisition of pre-screened plunge-frozen grids containing large complexes, viruses, or exosomes. It is intended for samples that do not require lamella preparation. Data are acquired on a Titan Krios microscope using automated tomography data acquisition workflows.
Availability: Physical and remote (data collection under supervision)
This service provides high-resolution single-particle cryo-EM data collection on pre-screened Quantifoil grids using automated acquisition workflows on a Titan Krios microscope. During the session, users can collect large datasets for structure determination, with real-time data processing available through cryoSPARC Live for immediate feedback on data quality and sample performance. This service is suitable for well-optimized samples that have already been screened and are ready for high-end data collection.
Availability: Physical and remote (data collection under supervision)
Average duration of visit: 2-3 days
This service supports users screening, and evaluating cryo-EM grids for high-resolution data collection. During the service session, up to 8 grids can be screened to assess overall sample suitability for high-end data acquisition, including check of ice quality, particle density and distribution. Optional grid preparation support can be provided upon request, depending on project needs and sample readiness. Initial data processing (motion correction, CTF estimation, and 2D classification) is included to assess data quality and guide next steps.
Availability: Physical and remote (data collection and processing under supervision)
Average duration of visit: 2 days
Used for sample screening (primarily purified protein complexes, vesicles), grid evaluation, EPU multigrid and cryoSPARC for fast evaluation. Tomography on thin samples is possible.
Physical access: Yes
Remote access: Yes (supervised sessions possible)
Software: Velox, EPU, TOMO
High-end cryo-TEM for data collection of single-particle or tomographic tilt-series datasets at highest resolution.
Physical access: Yes
Remote access: Yes (under supervision)
Software: MAPS, EPU, TOMO or SerialEM, cryoSPARC live
Used for sample vitrification.
Physical access: Yes
Remote access: No
Used for sample vitrification.
Physical access: Yes
Remote access: No
