The Netherlands Centre for Electron Nanoscopy at Leiden University is the open access facility for cryo-EM in the Netherlands.
The Netherlands Centre for Electron Nanoscopy (NeCEN) at Leiden University is part of the Instruct-NL national Instruct Centre in the Netherlands and provides access to cryo-electron microscopy (cryo-EM).
The NeCEN microscopes are optimised for visualising cellular structures in 3D with nanometre precision (tomography) as well as equipped for analysing single particles with even more detail. Cryo-electron microscopy (cryo-EM) allows scientists to observe proteins and organelles in a near native state.
In addition to data collection, NeCEN offers a wide range or cryo-EM related services, including sample preparation, sample screening, image processing and specialized customer tailored trainings and courses.
NeCEN is currently available for remote access, as well as physical visits by scientists from EU countries, Schengen countries, UK, and select other countries but availability can be limited. Please check possibilities with a Centre representative. Receiving international visitors from other countries is currently not possible due to COVID-19 restrictions. For information on the availability of specific technologies, view the Technology Availability List or contact support@instruct-eric.eu. Please check here regularly for updates.
How to find us
NeCEN is an open access facility and additionally accessible through Instruct and iNEXT-Discovery. See the NeCEN website for detailed contact information.
NeCEN is an open access facility for high resolution cryo-electron microscopy of biological samples. A state-of-the-art Titan Krios transmission electron microscope allows efficient and automated high resolution data collection in its two most broadly used forms, single particle analysis (SPA) and cryo-electron tomography (cryo-ET). These imaging techniques allow visualisation of biomolecular structures, such as proteins, macromolecular complexes, bacteria, and cell organelles at subnanometer resolution in close-to-native conditions. The facility is equipped with a BSL2 lab and microscope rooms.
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