CiC bioGUNE


The NMR Facility at the CiC bioGUNE institute for biosciences near Bilbao (Spain) enables a broad range of solution state NMR studies.


The NMR facility of CiC bioGUNE, founded in 2005, has steadily expanded to now house five modern high-field solution state spectrometers (3x 600, 800, 1000 MHz) with vast accessory (including probeheads, automatic sample changers, mobile flow unit). From the beginning, it has offered access and expert services also to external academic and industrial customers, more recently through the Spanish ICTS program.

The ample high-end NMR equipment is complemented by strong inhouse competence for dedicated protein and glycan sample preparation with stable isotope (13C, 15N, 2H) or chemical (19F) labeling, for NMR methods development and optimisation, and for in-depth NMR data analysis. Thus, CiC bioGUNE can offer all services required for the most sophisticated biomolecular NMR studies on proteins and glycans, their molecular interactions, structure, dynamics, etc. Moreover, CiC bioGUNE offers its services along the entire chain of NMR metabolomics studies. The latter rely on two dedicated 600 MHz IVDr spectrometers, a completely equipped biofluid sample lab, custom software and databases, and specialised staff with a decade of experience in the field, from sample collection, preparation, NMR experimentation to full data analysis and presentation. All cited services for biomolecular (protein, glycan) and metabolomics studies by NMR can be ordered either as modules (e.g. for experienced users with some own resources) or as complete packages (for strangers in the field).

CiC bioGUNE NMR Facility

Ed. 800, Parque Cientifico y Tecnologico de Bizkaia

48160 Derio

Bilbao

Spain

CiC bioGUNE website

Visitor information


For detailed information on our NMR equipment and the NMR related services, please visit the website or contact staff directly.
Standard opening hours: Monday through Thursday 09:00 – 18:00; Friday 09:00 – 15:00
While we prefer physical access due to the complexity of NMR spectroscopic analyses, some remote access can be arranged for after prior consultation. Acquired NMR spectra will be deposited on a secure web server or sent to the customer via their preferred channels.

How to find

Visitors arriving at Bilbao international airport can reach CiC bioGUNE by taxi or by public BizkaiBus line A 2153 (exit at bus stop ‘Lekunbiz’ or ‘Teknologia Parkea – Innobasque’, then 10 minutes walk). The airport is well connected to Bilbao downtown by BizkaiBus line A 3247.
Visitors arriving by long distance bus at ‘Bilbao Intermodal’ station or staying in Bilbao can reach CiC bioGUNE by BizkaiBus lines A 3250 (faster) or A 3224 (slower), which leave from the central Plaza Moyua to the Technology Park of Bizkaia (Parque Tecnologico/ Teknologia Parkea). Exit at bus stop ‘Abeletxea/Granja’ in front of the ‘bioGUNE’ building 801 and follow the stairs and path to its right to arrive at building 800 housing the NMR platform.
Alternatively, take suburban train (EuskoTren) line L3 from old town Bilbao (station ‘Casco Viejo / Zazpikaleak’) to ‘Lezama’. Exit at ‘Zamudio’ station to take the connecting Euskotren bus into the Technology Park, again leaving at bus stop ‘Abeletxea/Granja’ (see above). Alternatively, leave already at ‘Lekunbiz’ station for a 15 minutes’ (1.7 km) straight walk to CiC bioGUNE.
Hotel options are numerous in Bilbao downtown. Alternatives in the Technology Park, within walking distance from the CiC bioGUNE, include Hotel “Aretxarte” (www.hotelaretxarte.com), “The Park” (hotelthepark.es), “Artea Errota” (www.arteaerrota.com), and “Seminario” (www.hotelseminariobilbao.com).


Other Services/Technologies at CiC bioGUNE:

The NMR Facility at the CiC bioGUNE institute for biosciences near Bilbao (Spain) enables a broad range of solution state NMR studies, with special focus on metabolomics and the analysis of molecular interactions, structures, and dynamics of proteins and glycans.

We primarily offer the acquisition of the broadest range of NMR spectra on customer provided samples, focusing on standard isotopes (1H, 2H, 13C, 15N, 19F, 31P)

Other services:

We furthermore offer assistance with:

  • protein, glycan, or glycoprotein sample preparation for NMR, optionally with diverse stable isotope [2H, 13C, 15N] labeling patterns
  • NMR methods implementation, optimisation, and development (to most flexibly adjust to customer needs)
  • measurement of complete NMR data sets for more sophisticated studies, e.g. on molecular interactions (NMR titration series), dynamics (NMR relaxation measure-ments), conformational ensembles (NOESY and NMR relaxation measurements)
  • analysis of acquired NMR spectra (e.g., signal assignment, analysis of molecular structure, dynamics, and interactions)
  • molecular dynamics simulations (primarily to complement experimental data from diverse NMR relaxation measurements)
  • NMR metabolics studies under calibrated SOPs (with or without subsequent statistical data analysis)
  • broad NMR consulting (on all topics and services mentioned) internally or externally (at customer facility)
  • remote implementation and supervision of NMR measurements (at customer facility)


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Beatriz Gonzalez
Beatriz Gonzalez
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X-Ray Crystallography Biochemistry and structural biology
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Oscar Millet
Oscar Millet
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